I am working as a Research Associate in the Department of Pure & Applied Chemistry at the University of Strathclyde, and GSK, Stevenage, UK, under the supervison of Prof. David Palmer and Dr Andrew Baxter
I am a computational scientist by training, but what really drives me in solving complex problems that make a tangible societal impact. I have a broad background in computational chemistry, chemical biology, medicinal chemistry and machine learning, with specific aims in Developing Data-Driven Approaches to the Design, Synthesis, and Evaluation of Next-Generation Molecules Beyond Lipinski Space. Prior to my work at Strathclyde, I worked as a Postdoctoral Research Associate at the Ineos Oxford Institute for Antimicrobial Research and the Department of Chemistry, University of Oxford, worked closely with the esteemed groups led by Prof. Christopher Schofield, FRS and Prof. Fernanda Duarte. My work involves bacterial proteins that inactivate or evade the action of antibiotics, specifically β-lactamases, transpeptidases and deacetylases, with the goal of exploring their mechanisms and developing resistance-breaking inhibitors that enable effective combination therapies against drug-resistant bacteria. Before Oxford, I also worked as a Postdoctoral Research Associate in Dr. Amanda Jarvis' group at The University of Edinburgh. I specialize in structurally modelling artificial metalloenzymes to enhance their efficiency while also innovating the design of new metalloenzymes. My approach integrates various computational techniques, spanning from molecular docking studies to hybrid QM/MM calculations. I was graduated with PhD degree in 2021 from The University of Manchester, where I worked with Dr. Richard Henchman and Prof. Samuel de Visser, FRS at Manchester Institute of Biotechnology. My research was focused on the Development and Implementation of Algorithms to Determine the Reactions Kinetics and Stability of Biomolecules.
March 2026: Started Research Associate position with Prof. David Palmer, at the University of Strathclyde, Scotland, UK.
March 2022: Started Postdoc with Prof. Christopher Schofield, FRS, at the University of Oxford, England, UK.
September 2021: Started Postdoc with Dr. Amanda Jarvis at the University of Edinburgh, Scotland, UK.
May 2021: Successfully defended my PhD dissertation without revisions, submitted my thesis, and graduated from The University of Manchester!
July 2019: My first paper from PhD work on Multiscale Cell Correlation (MCC) Theory is published!
February 2018: Started my PhD with Dr. Richard Henchman and Prof. Samuel de Visser, FRS, at The Manchester Institute of Biotechnology, The University of Manchester, UK.
August 2017: I was honored to receive the Chief Minister Merit Scholarship from the Government of Pakistan, enabling me to pursue my PhD at one of the Top 50 Universities in the world.
Sanja Brolih, Hafiz Saqib Ali, Caroline Scott, Aude-Anais Olijnik, Hazel Aitkenhead, Gemma Moir-Meyer, Angeline E. Gavard, Yuliana Yosaatmadja, Douglas R. Higgs, Veronica Buckle, Noemi Roy, Opher Gileadi, Joseph A. Newman, Fernanda Duarte, Christian Babbs, Peter J. McHugh
Nature Communications, 2026 (Accepted/in-press)
Ghalia Khoder, Esra M. Mustafa, Sumera Zaib, Anil Ravi, Afnan I. Shahin, Seyed-Omar Zaraei, Nehal Rana, Hanan S. Anbar, Hafiz Saqib Ali, Shamsul Qumar, Merylin Sebastian, Ragheb Alsheikh Zein, Mohammed I. El-Gamal
Gut Pathogens, 2026 18, 27.
Matthew J. Beech, Edmond C. Toma, Helen G. Smith, Maria M. Trush, Jit H.J. Ang, Mei Y. Wong, Chung H.J. Wong, Hafiz Saqib Ali, Zakia Butt, Viha Goel, Fernanda Duarte, Alistair J.M. Farley, Timothy R. Walsh, Christopher J. Schofield
Chemical Science, 2025, 16, 9691-9704.
Anil Ravi, Sumera Zaib, Shabab Zahra, Imtiaz Khan, Hafiz Saqib Ali, Mohammed Ibrahim El-Gamal, Hanan Sayed Anbar
European Journal of Medicinal Chemistry, 2025, 291, 117584
Hafiz Saqib Ali, Sam P. de Visser
Chemistry: A European Journal, 2024, e202304172.
Probing Ferryl Reactivity in a Nonheme Iron Oxygenase Using an Expanded Genetic Code
Florence J. Hardy, Matthew G. Quesne, Emilie F. Gérard, Jingming Zhao, Mary Ortmayer, Christopher J. Taylor, Hafiz Saqib Ali, Jeffrey W. Slater, Colin W. Levy, Derren J. Heyes, J. Martin Bollinger, Jr., Sam P. de Visser, Anthony P. Green
ACS Catalysis, 2024, 14, 11584–11590.
Catalytic Divergencies in the Mechanism of L-Arginine Hydroxylating Nonheme Iron Enzymes
Hafiz Saqib Ali, Sam P. de Visser
Frontiers in Chemistry, 2024, 12, 1-14.
Hafiz Saqib Ali, Jim Warwicker, Sam P. de Visser
ACS Catalysis, 2023, 13, 10705–10721.
Hafiz Saqib Ali, Richard Henchman
Physical Chemistry Chemical Physics, 2023, 25, 27524-27531.
Impact of Counteranions on N-heterocyclic Carbene Gold(I)-Catalyzed Cyclization of Propargylic Amide
Hafiz Saqib Ali, Aqeel A. Hussein, Mohammed Obies
RSC Advances, 2023, 13, 2896-2902.
Hafiz Saqib Ali, Sam P. de Visser
Chemistry: A European Journal, 2022, 16, e202104167.